Wayne Rooney has had a disappointing start to life as Birmingham manager, losing his first two matches in charge of the Blues without scoring.
They face a tough task in their third game under the former England striker, visiting a resurgent Southampton side that are unbeaten in their last five games and are up to fifth in the second tier as a result.
Southampton will welcome back Ryan Manning after his one-game suspension but Jack Stephens, Ross Stewart and Juan Larios are still injured.
Che Adams and Taylor Harwood-Bellis are also doubts for the Saints.
Juninho Bacuna is suspended for Birmingham after picking up his fifth yellow card of the season.
George Hall, Ethan Laird, Tyler Roberts, Keshi Anderson, Lee Buchanan and Alfie Chang also remain sidelined for the visitors.
No team has conceded more goals in the Championship this season than Southampton’s
Five of the Saints’ six league victories this season have been by one goal.
No Championship team has played more games with four or more goals this season than Russell Martin’s have.
Southampton are unbeaten in their last five games, winning three and drawing the other two.
Birmingham have lost both of their games under new manager Wayne Rooney.
These two teams have not met in over 10 years, with their last match a 0-0 draw in February.