The victim, a man in his 20s, was left fighting for his life in hospital after the stabbing in Laburnum Road on Thursday October 26, near to the Daisy Dip playground.
Thankfully, he has since been discharged.
Asma Mokhtar, 45, from Bluebell Road, Southampton, has been charged with attempted murder and grievous bodily harm with intent.
She has been remanded in custody.
Two teenage boys, aged 17 and 15 from Southampton, have also been charged with attempted murder and grievous bodily harm with intent.
They cannot be named for legal reasons, and have been released on conditional court bail.
They all appeared at Southampton Magistrates’ Court this afternoon.
They are all due to appear at Southampton Crown Court on Friday November 17th.
A spokesperson for Hampshire & Isle of Wight Constabulary said: “Our investigation into this incident is continuing and we would still like to hear from anyone we have not yet spoken to, who may have information to assist our enquiries.
“Anyone with information who we have not yet spoken to is asked to call 101 quoting reference 44230439124.”
